杉本 和久, 他(2005)「ハイドロキノン配糖体のチロシナーゼ阻害効果およびα-アルブチンのメラニン生成抑制効果」Fragrance Journal(33)(5),60-66. 99 likes. Hope that will help you. We studied the inhibitory effects of 4-hydroxyphenyl alpha-glucopyranoside (alpha-arbutin) on melanogenesis in cultured human melanoma cells, HMV-II, and in a three-dimensional cultured human skin model. We found that arbutin both inhibits melanin production in B16 cells induced with alpha-MSH and decreases tyrosinase activity in a cell-free system. Dengan kandungan lactic acid yang dapat membantu mengeksfoliasi kulit dan melembapkan, serta niacinamide yang membantu merawat kulit. Apply a few drops in the morning and evening. The Ordinary Alpha Arbutin 2% + HA $11 Shop This concentrated serum combines purified alpha arbutin with hyaluronic acid to reduce the look of spots and hyper-pigmentation thereby improving uneven skin tone. Alpha Arbutin, when used in large amounts, can also associate other side effects such as skin irritation that can transform into skin acne. Once you feel the Alpha Arbutin has been absorbed you can apply the next product. Usage of arbutin: apply 2-3 drops How it works: arbutin turns into hydroquinone in the body, inhibiting the production of tyrosinase and interfering with the maturation of melanosomes (organelles involved in melanin production). This treatment fades hyperpigmentation (such as dark spots, acne scars, age spots, and melasma) and promotes a clear, even skin tone. Alpha arbutin is expensive to manufacture which is why usually only high quality products contain this ingredient. [Learn more about how to check your skincare ingredients]. Note: Alpha Arbutin is extremely sensitive to degradation in the presence of water if the pH of the formulation is not ideal. Arbutin may be made synthetically or derived from bearberry (uva-ursi) plant or other plants and exhibits antioxidant activity. My thoughts on The Ordinary Alpha Arbutin 2% + HA. How to use Alpha Arbutin 2% +HA. Kojic Acid.

Jessica L. Yarbrough is a writer based in Joshua Tree, California, whose work can be found on The Zoe Report, Marie Claire, SELF, Cosmopolitan, and Fashionista.com. It is, therefore, considered that Alpha-Arbutin is an effective and safe ingredient for cosmetics. But there’s Salicylic acid, Vitamin C, retinol and Alpha Hydroxy Acids (AHAs) are a few popular ingredients that have reigned supreme in skin care products. Worst: Alpha Arbutin 2% + HA Such was my disdain for the Alpha Arbutin 2% + HA that I gave it away before taking a photo! If you wish to incorporate multiple Retinoids, and/or Direct Acids into your skincare regimen, we suggest using them on alternate evenings and waiting until your skin has adjusted to … Can I use The Ordinary Alpha Arbutin, Niacinamide and Retinol in the same routine? There are other arbutins out there that may have higher risks. This video is about how to use alpha Arbutin and is it actually work full for our skin or not. It can be used in the morning and evening by applying just a couple of drops to cleansed skin. Medical definition of arbutin: a crystalline glucoside C12H16O7 found in the leaves of various plants (as the bearberry) of the heath family (Ericaceae) and sometimes used as a urinary antiseptic. 一般的に化粧品および医薬部外品(薬用化粧品)の成分表示に「アルブチン」と記載されているアルブチンは、α-アルブチンの構造異性体であるβ-アルブチンであり、β-アルブチンの色素沈着抑制効果および安全性はすでに詳しく報告されています。, チロシナーゼ阻害による色素沈着抑制作用に関しては、まず前提知識としてメラニン生合成のメカニズムおよびチロシナーゼについて解説します。, 紫外線を浴びるとまず最初に活性酸素が発生し、様々な情報伝達物質(メラノサイト活性化因子)をメラノサイトで発現するレセプター(受容体)に届けることで、メラノサイト内でメラニンの生合成がはじまり、ユーメラニン(黒化メラニン)へと合成されます。, メラノサイト内でのメラニン生合成は、まずアミノ酸であるチロシンに活性酵素であるチロシナーゼが結合し、チロシンが酸化することでドーパ、ドーパキノンへと変化し、最終的に黒化メラニンが合成されます。, このような背景からチロシナーゼ活性を抑制・阻害し、チロシンとの結合を阻害またはチロシンとの結合量を減らすことは、色素沈着防止という点で重要であると考えられます。, 2007年に江崎グリコによって報告されているα-アルブチンのチロシナーゼに対する阻害効果検証によると、, 一方で、α-アルブチンのチロシナーゼに対する阻害作用についても複数の研究グループによって研究が行われており、α-アルブチンとβ-アルブチンのマッシュルーム由来、B16マウス由来およびヒト由来メラノーマ細胞のチロシナーゼに対する阻害作用について比較したところ、以下の表のように(∗1)、, ∗1 IC₅₀値とは、50%阻害に必要な濃度のことであり、数値が低いほど作用が強いことを意味します。, α-アルブチンは、マッシュルーム由来チロシナーゼを阻害しなかったが、β-アルブチンは阻害作用を示した。, 一方で、α-アルブチンは、マウス由来チロシナーゼをβ-アルブチンに比べて協力に阻害した。, またα-アルブチンの化粧品への応用を考慮した場合、ヒト由来チロシナーゼに対する阻害作用が重要であるが、ドーパを含むヒト由来メラノーマ細胞を用いた場合、α-アルブチンは、β-アルブチンよりも強力にヒトチロシナーゼを阻害した。, α-アルブチンとβ-アルブチンの各種チロシナーゼに対する阻害効果の違いは、チロシナーゼ蛋白の構造と密接な関係があると考えられており、マッシュルーム由来チロシナーゼとヒトチロシナーゼのアミノ酸配列の同一性は23%でしかなく、マウス由来チロシナーゼとヒトチロシナーゼ間の同一性は82%とかなり高い相同性を有していることから、メラニン生成抑制のスクリーニングにはヒトチロシナーゼの指標が重要であると考えられた。, これらの結果および考察から、ヒトチロシナーゼを強力に阻害するα-アルブチンは、β-アルブチンよりも優れたチロシナーゼ阻害剤となりうると考えられる。, このような検証結果が明らかになっており(文献4:2007;文献5:1995;文献6:2003)、α-アルブチンにチロシナーゼ阻害による色素沈着抑制作用が認められています。, α-アルブチンのチロシナーゼ阻害作用は、α-アルブチンの添加によりチロシナーゼmRNA量に変化が認められなかったことから、チロシナーゼ遺伝子発現の抑制によるものではなく、α-アルブチンが細胞内に取り込まれ、チロシナーゼを直接阻害することにより発揮していると考えられています(文献7:2005)。, また、α-アルブチンはハイドロキノン誘導体ですが、α-アルブチンのチロシナーゼ阻害作用は、α-アルブチン自体によるものであり、α-アルブチンはグルコースとハイドロキノンに分解されないことが確認されています(文献3:1995)。, 次に、2005年に江崎グリコによって報告されているヒト皮膚モデルにおけるα-アルブチンのメラニン生成抑制効果検証によると、, α-アルブチンを添加した場合、メラニン生成量は、125μgおよび250μgで70%および40%に抑制されていることが確認された。, このような検証結果が明らかになっており(文献7:2005)、α-アルブチンにメラニン生成抑制による色素沈着抑制作用が認められています。, また、紫外線照射による色素沈着に対して、α-アルブチンとUVA吸収剤であるメチレンビスベンゾトリアゾリルテトラメチルブチルフェノールを併用することで、それぞれ単体で配合するよりも大幅に色素沈着を抑制することが報告されています(文献7:2005)。. ini cukup menarik. The Ordinary Alpha-Arbutin 2 % + HA EUR 8,45 – een serum dat hyperpigmentatie en vlekjes minder zichtbaar zou moeten maken. Alpha Arbutin and Niacinamide are two key ingredients that women who want to get rid of dark spots, melasma, hyperpigmentation just love. It is much stronger in effect than Arbutin or Beta Arbutin.Note: Alpha Arbutin is extremely sensitive to degradation in the presence of water if the pH of the formulation is not ideal. It's used at a high 2% concentration versus a standard concentration of 1% and supported with a next-generation form of Hyaluronic Acid for enhanced delivery. I’ve heard hydroquinone is bad, so I did some research and found the “Alpha Arbutin While alpha arbutin is proven to be safe and effective when it comes to skin lightening, there’s a limit on how much you can use. Alpha Arbutin is used at a high 2% concentration versus a standard concentration of 1% and supported with a next-generation form of Hyaluronic Acid for enhanced delivery. Hey, you can try The Ordinary Alpha Arbutin 2% + HA, it works really well for pigmentation issues and make sure you don’t skip sunscreen at any cost whenever you step out. (adsbygoogle = window.adsbygoogle || []).push({}); これらの結果から、化粧品配合量および通常使用下において、一般的に安全性に問題のない成分であると考えられます。, Scientific Committee on Consumer Safetyの安全性データ(文献1:2015)によると、, 試験データをみるかぎり、共通して皮膚刺激性および皮膚感作性なしと報告されているため、皮膚刺激性および皮膚感作性はほとんどないと考えられます。, また、長時間の皮膚接触が皮膚刺激を引き起こす可能性があるという記述がみられるため、注意が必要だと考えられます。, 試験データによると、最小限の眼刺激性が報告されているため、10%以下濃度において、最小限の眼刺激性が起こる可能性があると考えられます。, 試験データをみるかぎり、共通して光毒性および光感作性なしと報告されているため、光毒性および光感作性はほとんどないと考えられます。, α-アルブチンはハイドロキノン誘導体ですが、α-アルブチンが皮膚に作用するメカニズムはα-アルブチン自身によるものであり、皮膚に浸透する際に分解・代謝を通じてグルコースから遊離したハイドロキノンによるものではないことが確認されています(文献3:1995)。, "化粧品成分オンライン"は化粧品成分上級スペシャリスト資格取得者が記事を執筆し、情報信頼性の高いサイトを目指しています。, β-アルブチンのメラニン生成抑制効果の主要メカニズムは、メラニン合成のキー酵素のひとつであるチロシナーゼ阻害であると考えられている。, 正常ヒト皮膚3次元モデルにα-アルブチン水溶液125μgあるいは250μgを1日おきに13日間培養し、培養終了後にメラニン量を測定したところ、以下のグラフのように、. Moreover, Alpha-Arbutin hardly inhibited cell growth at 1 mmol/L, while Beta-Arbutin inhibit it significantly at the same concentration. The good kind are known as "purging" or an "initial breakout"—and it's worth suffering through the process, because on the other side is better skin. Best Alpha Arbutin Products reviews. #acne #acnetreatment #isotretinoin #skincare #skincaretips #makeup #acnescars #skincareroutine #skincareproductsCan you combine Benzoyl Peroxide and Alpha Arbutin?

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